a blister, callous, or a venereal tumor(?) (see Molina)
Orthographic Variants:
xoxale
IPAspelling:
ʃoʃɑlli
Alonso de Molina:
xoxalli. lobado, lobanillo o potra. Alonso de Molina, Vocabulario en lengua castellana y mexicana y mexicana y castellana, 1571, part 2, Nahuatl to Spanish, f. 161v. col. 1. Thanks to Joe Campbell for providing the transcription.